Manchester United have won 17 of their 21 Premier League home matches against West Ham with just two wins for the Hammers and two draws.
West Ham have not won at Old Trafford for ten years since they avoided relegation thanks to the famous Carlos Tevez winner.
Manchester United have only lost one of their 13 opening-day Premier League fixtures at Old Trafford (W9, D3) – a 2-1 defeat by Swansea City in 2014.
Jose Mourinho has never lost a home match on a Sunday in his managerial career, winning 86 and drawing 26 of his 112 games in all competitions.
The Manchester United manager has also never lost on the opening day of a Premier League campaign (W7, D1).
Romelu Lukaku has scored in seven of his last eight games against West Ham.
West Ham have lost ten opening-day fixtures, more than any other Premier League club.
Bookies Bet365 are offering odds of 11/1 for a West Ham win, the draw is 9/2 from Betway while a West Ham loss is an odds-on price of 1/3 with Betvictor.