Unsurprisingly David Moyes has had to make two enforced changes to the team which beat Wolverhampton Wanderers last weekend, replacing the injured Jarrod Bowen and suspended Edson Álvarez with Michail Antonio and Aaron Cresswell.
Both Antonio and Cresswell played big roles in the 2-1 Premier League win at Molineux and they are rewarded with starts in that looks to be a 3-4-2-1 formation, with Vladimír Coufal and Emerson filling wing-back positions.
Ahead of them, Tomáš Souček and James Ward-Prowse will be vital, with their work-rate and stamina expected to be tested by a strong Bayer Leverkusen team
West Ham United: Fabiański, Coufal, Zouma ©, Mavropanos, Cresswell, Emerson, Souček, Ward-Prowse, Kudus, Paquetá, Antonio
Subs: Anang (GK), Knightbridge (GK), Johnson, Ogbonna, Aguerd, Casey, Orford, Earthy, Cornet, Ings, Mubama
COYI !!