David Moyes has made three changes from the match against Bristol City as he bids for victory at Sheffield United.
Alphonse Areola returns in goal whilst Jarrod Bowen and Pablo Fornals come in for Aaron Cresswell and Saïd Benrahma
Danny Ings makes his second consecutive start alongside Bowen in attack, as well as Maxwel Cornet.
Kurt Zouma joins Dinos Mavropanos in the centre of defence with Vladimír Coufal and Emerson . Ahead of them, James Ward-Prowse and Tomáš Souček line up in midfield.
Callum Marshall after again being named on the bench, will be hoping for more minutes after being handed his debut against Bristol City, while 17-year-old Lewis Orford could make his first senior appearance if called upon by Moyes.
The likes of Kaelan Casey, Ollie Scarles and Divin Mubama will again be looking to make an impact, with both Casey and Scarles aiming to build on their first-team debuts against FCSB in the UEFA Europa Conference League last season.
Sheffield United: Foderingham, Bogle, Ahmedhodzic ©, Robinson, Trusty, Souza, McAtee, Hamer, Brooks, Brereton Díaz, Osula
Subs: Amissah (GK), Brewster, McBurnie, Archer, Norwood, Osborn, Norrington-Davies, Seriki, Buyabu
West Ham : Areola, Coufal, Zouma ©, Mavropanos, Emerson, Cornet, Souček, Ward-Prowse, Fornals, Ings, Bowen
Subs: Fabiański (GK), Johnson, Cresswell, Ogbonna, Casey, Mubama, Marshall, Scarles, Orford