The Irons will be without Angelo Ogbonna through suspension after the Italy centre-back was booked for a third time in the competition in Belgium last week.
Gianluca Scamacca is also out after undergoing surgery to repair the meniscus in his knee at the weekend and the expectation is that he will not be back before the end of the season.
However, Nayef Aguerd who missed Sunday’s 2-2 Premier League draw with Arsenal with a knock suffered in the first leg in Gent looks likely to return.
KAA Gent have been without striker Darko Lemajić (groin), midfielder Andrew Hjulsager (Achilles) and defensive midfielder Sulayman Marreh (leg) in recent weeks.
Star forward Gift Orban was rested from the starting XI for their 1-1 Pro League draw at Mechelen on Sunday, while UECL regular Davy Roef is expected to replace Pro League regular Paul Nardi in goal.
Those who can’t get to the game can watch the tie live in the UK by BT Sport 2 and BT Sport Ultimate, with kick-off at 8pm GMT.