Manchester United manager Erik ten Hag will be without Argentina defender Lisandro Martinez (ankle/foot), Dutch midfielder Donny van de Beek (knee), Scotland midfielder Scott McTominay, France centre-back Raphaël Varane and goalkeeper Tom Heaton (ankle) for the match against the Hammers.
However, winger Alejandro Garnacho could be available.
As reported David Moyes will hope to welcome Declan Rice, Tomáš Souček and Nayef Aguerd back after the trio were ruled out of Wednesday’s match at Manchester City through illness. Vladimír Coufal was replaced during the same game with a hamstring injury.
One player who will definitely miss out, however, is striker Gianluca Scamacca, who has undergone surgery on his knee issue.
The two sides meet in the Premier League for the 54th time on Sunday.
The visitors have had the best of things down the years, winning 33 of the 53 previous meetings, while the Hammers have won seven, with 13 draws.
Of those seven wins, five have come at home – with three arriving in the last six seasons. After defeating the Red Devils 3-2 in the final Boleyn Ground game in May 2016, the Hammers recorded back-to-back home victories against Sunday’s opponents in September 2018 and September 2019, by 3-1 and 2-0 scorelines respectively.
David Moyes has faced Manchester United 36 times during his managerial career, 24 of them with Everton, two with Sunderland and ten with West Ham United, winning five, drawing seven and losing 24.
Moyes also managed Manchester United 51 times during the 2013/14 season, winning 26, drawing ten and losing 15, including home and away Premier League victories over West Ham.