West Ham and Southampton have played 177 games since their first game on 16 December 1899
The Hammers have won 80 games, drawn 47 and 50 against the Saints.
West Ham have won six of the past seven top-flight meetings, scoring 15 goals and conceding just twice.
The Hammers have won 19 Premier League games versus Southampton, more than against any other side.
Ralph Hasenhuttl’s team have lost an unrivalled 16 Premier League games in 2021.
Southampton have dropped five points in this season’s top flight, which is a joint high with Newcastle.
They have kept just one clean sheet in their past 24 league matches.
West Ham are vying to remain unbeaten after their opening four Premier League matches for just the second time, having done so under Harry Redknapp in 1999.
The Hammers have scored at least twice in each of their first three games – the last time they did so in their opening four top-flight fixtures of a season was in 1929.
They have scored 100 top-flight goals since David Moyes returned to the club in January 2020. Only Manchester City, Manchester United and Liverpool have also reached triple figures during this period.
Michail Antonio has both scored and assisted in three successive appearances – no player has ever done so in four consecutive Premier League fixtures.
Pablo Fornals has scored four goals in his last four league games, as many as he had in his previous 50 for the Hammers.