Injuries cost West Ham a total of £12.8 million last season according to a new formula recognised by Uefa.
According to a report in the Mail on line the bill across the League amounted to £270 million last season, with Newcastle and Arsenal both suffering bills in excess of £20m.
On average, Premier League clubs lost £13.5m to injuries in the 2014-15 campaign, with Everton and Manchester United suffering the third and fourth largest costs approaching £20m.
The full price paid by clubs for an injury is detailed in a new UEFA-recognised formula that calculates the monthly costs of an injured player.
It has been found that Premier League and leading European clubs pay out an average of £413,000 a month for every player injured.
The calculation for how much an injured player costs his club was designed by Sergei Palkin, chief executive of Ukrainian high-fliers Shakhtar Donetsk.