West Ham and Manchester have faced each other 146 times since they first played in February 1911 in the FA Cup. A game the Hammers won 2-1
West Ham have won 45 matches, drawn 32 games and lost 69 encounters.
West Ham have won just seven of their 50 Premier League matches against Manchester United (D13, L30).
The Hammers are unbeaten after their opening four Premier League matches for the first time since 1999.
They could equal the club Premier League record of five games undefeated from the start of the season.
West Ham lost seven of their eight matches against the teams who finished in the top four last season, drawing the other.
David Moyes has won only three of his 28 Premier League fixtures as a manager against Manchester United (D7, L18). All three victories came while in charge of Everton at Goodison Park.
Manchester United are unbeaten in 28 Premier League away games, the longest run without defeat on the road in English league history.
The Red Devils have conceded just 19 goals during this run, keeping 13 clean sheets.
This is only the second time in 10 seasons that Manchester United have been unbeaten after their opening four league fixtures. They also had 10 points at this stage in 2017.
Cristiano Ronaldo has scored five goals in four Premier League appearances versus West Ham.