Manuel Lanzini is back in the West Ham squad for the trip to the south coast after completing his two-match suspension. Mark Noble will miss out again with a tight hamstring and defender Jose Fonte remains a long-term absentee sidelined due to an ankle injury.
Joe Hart could replace Adrian in goal after the Spanish keeper conceded three on Saturday at the London Stadium.
Possible lineup: Hart, Reid, Ogbonna, Cresswell, Zabaleta, Kouyate, Obiang, Arnautovic, Lanzini, Antonio, Hernandez