Both were injured during Sunday’s defeat at Southampton and neither looks likely to recover in time for a game from which both sides see three points as crucial.
However, Unsworth added that Mason Holgate has returned to training after overcoming a groin problem and will be reassessed on Tuesday evening.
Unsworth said: “Leighton looks like he’s going to be out but both are probably doubtful for Wednesday night,” said Unsworth at his pre-match press conference.
“Mason trained yesterday, which is great. We’ve got a session tonight – we wanted to give the players as much rest as we could and give injuries every chance to recover, so we put training back. ”
This could be Unsworth’s last game in charge with former Irons boss Sam Allardyce now strongly linked with the job.