It means the injury worries are building up at a crucial time and the Spanish midfielder joins Angelo Ognonna, Andiry Yarmolenko, Darren Randolph, Fredericks himself, and Arthur Masuaku who are all at various stages of the comebacks.
With Jesse Lingard unavailable the immediate thought was that Moysie would call up DSaid Benrahma but he was left on the bench along with Manu Lanzini – another carrying a knock.
Instead Mark Noble joins the midfield and Jarrod Bowen returns to the team on the right side of midfield.
Meanwhile United are without Paul Pogba but Marcus Rashford is included despite taking a knock in the match against Man City last weekend.
UNITED: Henderson, Wan-Bissaka, Lindelof, Maguire (c), Shaw, McTominay, Fred, Greenwood, Fernandes, James, Rashford
Subs: Grant (GK), Bishop (GK), Bailly, Alex Telles, Williams, Tuanzebe, Matic, Diallo, Shoretire
It’s our 25th visit to Old Trafford in the Premier League and we kick off looking for what wpild be only our third win following two 1-0 victories.