Former Spain and Real Madrid full-back Arbeloa is understood to be ready to make his Hammers bow while 20-year-old Swiss midfielder Fernandes is also in line after his £5.5 million summer switch from FC Sion.
Darren Randolph is expected to come in for first-choice goalkeeper Adrian in the third round tie, but Winston Reid, Andy Carroll, Aaron Cresswell and Andre Ayew are still on the sidelines.
Provisional squad: Adrian, Randolph, Arbeloa, Byram, Masuaku, Collins, Ogbonna, Oxford, Kouyate, Nordtveit, Obiang, Fernandes, Noble, Payet, Lanzini, Antonio, Feghouli, Tore, Quina, Zaza, Fletcher, Calleri.