The front man has seen much action under Alan Pardew but came off against Arsenal last week and could be out for around a month.
Palace are also without Marouane Chamakh leaving a choice of Glenn Murray or Dwight Gayle to lead the line although Shola Ameobi may enter the reckong.
West Ham are without Carlton Cole and Andy Carroll so new-boy Nene (pictured above) is set to be in the squad for the first time.