West Ham could claim a league double against Manchester United for the first time since the 2006-07 season.
The Hammers have only lost two of the past eight league meetings (W2, D4).
However, United are unbeaten in the last 10 meetings at Old Trafford, winning eight and drawing two.
Manchester United have lost four of their past five matches in all competitions.
They could lose three consecutive league and cup fixtures for the first time since September 2016.
The Red Devils have not kept a clean sheet for eight games in all competitions – their longest run since a 10-match sequence in 2012.
Romelu Lukaku has scored in five successive home appearances against West Ham in the Premier League.
The Hammers are winless in seven league away games, losing six and scoring just one goal.
West Ham have kept just five Premier League clean sheets this season – only Fulham have recorded fewer.
Lukasz Fabianski has made a Premier League-high 134 saves this season, 21 more than nearest rival David de Gea prior to the weekend.