Wayne Rooney, Will Keane, Luke Shaw and Ashley Young are all out and Antonio Valencia and Adnan Januzaj played for the under-21’s on Friday night so are unlikely to be ready.
Juan Mata is banned after his red card against West Brom last week and Phil Jones and Cameron Borthwick-Jackson are unlikely to be involved due to fitness.
Chris Smalling is back fit and in the heart of the United defence and he said: “They are in good form and they will attack us, so it’s not a game where we will attack and they will just defend. Hopefully that will benefit us.
“I’ve played many rounds in recent years with United but we have not been able to win the trophy and that is something I want to deliver.”