David Moyes will need to make changes to the West Ham team that beat Rapid Vienna in the Europa League game last month.
Alex Kral tested positive for COVID after his international break and unless it can be proved to be a false positive he will remain in self isolation.
Captain Mark Noble suffering a knock to his hip and is still recovering. Eye witnesses saw he him with a limp on Monday and he has not resumed training.
Ben Johnson played on Sunday so there will be question marks over him and Cresswell whether they can play three games in eight days.
Whether Antonio can play all three games also remains a big question with the manager unlikely to take too many chances with his only striker.
Against the Austrian team Moyes started with Areola, Johnson, Dawson, Diop, Cresswell, Noble, Rice, Yarmolenko, Vlasic, Benrahma,Antonio
Whatever happens we will see some changes on Thursday night when the Hammers face Genk at the London Stadium