Jadon Sancho may well get his first full run out which if he excels could push Jesse Lingard back down the United pecking order.
The Manchester Evening Nws is claiming that 18-year-old Spaniard Alvaro Fernandez could make the nine-man bench and be in contention for a surprise debut.
And Alex Telles – who missed pre-season through an ankle injury could be involved with Diogo Dalot possibly coming in at left back. Edinson Cavani could well get a run out up front.
The Hammers look likely to play a much changed team with goalkeeper Alphonse Areola makin his Hammers debut and with Ryan Fredericks, Issa Diop reappearing in the back line.
Tomas Soucek could easily be rested for Alex Kral or Mark Noble with Pablo Fornals too maybe earning a rest after a busy spell.
The big question appears to be whether there will be a return for Mikey Antonio or if Jarrod Bowen will again lead the attack – a job in which he was successful on Saturday.