Everton are on target to lose three straight league matches against West Ham for the first time since a run of four between April 1929 and December 1931.
West Ham are unbeaten in six league games at the London Stadium and could win four successive top-flight home matches for the first time since May 2002.
The Hammers have scored nine goals in their past three home fixtures.
Manuel Pellegrini has never lost in seven previous Premier League games against Everton, winning five of them.
Manuel Lanzini has scored three league goals in three home appearances for West Ham against Everton.
If selected, Angelo Ogbonna will become the second Italian, after Paolo Di Canio (118), to make 100 Premier League appearances for West Ham.
Everton are winless in their last 10 league games played in London, losing seven of them, since a 1-0 win at Crystal Palace in January 2017.