Cheikhou Kouyate is back in the West Ham squad having returned from the African Nations Cup while right-back Sam Byram felt his hamstring after the midweek 4-0 defeat by Manchester City and will be assessed.
Saints’ new striker Manolo Gabbiadini will also be involved, although manager Claude Puel has yet to decide whether to hand him a place in the starting line-up.
Robert Snodgrass look set to make his full debut after an impressive outing as sub against Manchester City with Jose Fonte making a quick return to his former club.
Southampton have defender Virgil van Dijk out with an ankle injury ahead of our visit.
But Jay Rodriguez and James Ward-Prowse are back in training after spells out and could be added to the squad.